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Authors
Affiliations
1 Sardar Patel College of Technology,
(B-Pharmacy) Balaghat, Dis. Balaghat,
(M.P.) – 481001, IN
2 K.I.E.T. School of Pharmacy, Gaziabad, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 1 (2012), Pagination: 1-13
Abstract
Gastro-retentive floating drug delivery systems have emerged as an efficient means of enhancing the bioavailability and controlled delivery of many drugs. The controlled gastric retention of solid dosage forms may be achieved by the mechanisms of mucoadhesion, flotation, sedimentation, expansion, modified shape systems, or by the simultaneous administration of pharmacological agents that delay gastric emptying. Based on these approaches, classification of floating drug delivery systems (FDDS) has been described in detail. In vivo/in vitro evaluation of FDDS has been discussed by scientists to assess the efficiency and application of such systems. Several recent examples have been reported showing the efficiency of such systems for drugs with bioavailability problems.
Keywords
Gastro-Retentive Floating Drug Delivery, Mucoadhesion, Flotation, Sedimentation, Expansion, Modified Shape Systems, Gastric Emptying.
